What it is used for
- Reducing stroke risk in people with atrial fibrillation
- Treating and preventing blood clots in the legs (DVT) and lungs (PE)
- Preventing clots after some hip or knee operations
How it works
Dabigatran blocks thrombin, a central enzyme in the clotting cascade. By stopping thrombin from working, it makes the blood less likely to form harmful clots.
How it is taken
Usually supplied as oral capsules that must be swallowed whole and kept in their original packaging to protect them from moisture. It is typically taken twice a day with water, with or without food. Take it exactly as your doctor or pharmacist directs and do not open or crush the capsules.
No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.
Common side effects
- Indigestion or heartburn
- Tummy pain
- Easy bruising
- Nosebleeds or bleeding gums
- Nausea
Serious effects — get help
- Heavy or uncontrolled bleeding, blood in urine or stools, black/tarry stools, vomiting or coughing up blood - seek urgent care
- Sudden severe headache, weakness or confusion (possible brain bleed) - emergency
- Serious fall or head injury while taking it - get checked
- Serious allergic reaction: facial or throat swelling, trouble breathing
If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.
Interactions to watch
- Other blood thinners and aspirin
- Anti-inflammatory painkillers (NSAIDs)
- Certain heart-rhythm medicines and some antifungals
- Rifampicin and St John's Wort
- Some indigestion medicines may affect absorption
Who should take care
- Keep capsules in their original blister or bottle - do not transfer to a pill organiser, as they absorb moisture
- Generally avoided in pregnancy and breastfeeding - tell your clinician
- Report any kidney problems, as the medicine is cleared by the kidneys
- Tell any doctor, dentist or surgeon you take it before procedures
- Do not stop suddenly without advice