What it is used for
- Nerve (neuropathic) pain
- Epilepsy (as an add-on for certain seizures)
- Generalised anxiety disorder (in some regions)
- Fibromyalgia (in some regions)
How it works
Pregabalin attaches to a part of nerve cells (calcium channels) that affects the release of signalling chemicals, which calms overactive nerve signals involved in pain, seizures and anxiety.
How it is taken
Usually available as capsules, tablets and an oral liquid. It is taken by mouth, with the amount usually increased gradually. Take it exactly as your doctor or pharmacist directs and follow the label; do not stop suddenly, as withdrawal effects can occur.
No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.
Common side effects
- Drowsiness
- Dizziness
- Blurred vision
- Weight gain
- Dry mouth
- Swelling of hands or feet
- Difficulty concentrating
- Unsteadiness
Serious effects — get help
- Slowed or shallow breathing, especially with opioids or other sedatives (seek emergency help)
- Mood changes or suicidal thoughts
- Severe allergic reaction (swelling of face, lips or throat, trouble breathing)
- Severe dizziness or fainting
- Muscle pain or weakness with feeling unwell
- Dependence and withdrawal symptoms if stopped abruptly
If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.
Interactions to watch
- Opioid painkillers (dangerous combined sedation and breathing suppression)
- Alcohol and other sedatives (added drowsiness)
- Other medicines that cause drowsiness
- Medicines that cause fluid retention or swelling
Who should take care
- Has potential for misuse and dependence; it is a controlled medicine in some regions
- Do not combine with opioids or alcohol without specialist supervision because of breathing risk
- Use with caution and possible dose adjustment with kidney problems
- Tell your clinician if you are pregnant, planning pregnancy or breastfeeding
- Do not stop suddenly; taper under medical guidance, and avoid driving if affected