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Anticonvulsant (anti-seizure)

Levetiracetam: uses, side effects & precautions

Also known as Keppra.

Queste informazioni hanno carattere puramente orientativo e non costituiscono un parere medico. Consulta sempre un professionista sanitario qualificato per problemi medici personali. In caso di emergenza, chiama il numero di emergenza locale.

What it is used for

  • Epilepsy (several seizure types, alone or with other medicines)

How it works

Levetiracetam is thought to work by binding to a protein in nerve endings that influences how nerve signals are released, helping to reduce abnormal electrical activity that causes seizures.

How it is taken

Usually available as tablets, an oral liquid and an injection used in hospital. It is taken by mouth, usually with the amount built up gradually. Take it exactly as your doctor or pharmacist directs and follow the label; do not stop suddenly, as this can trigger seizures.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Drowsiness
  • Tiredness
  • Dizziness
  • Headache
  • Irritability
  • Stuffy nose or sore throat
  • Reduced appetite

Serious effects — get help

  • Mood and behaviour changes: depression, severe irritability, aggression, agitation, or suicidal thoughts (seek advice promptly)
  • Severe allergic or skin reactions (rash, blistering, swelling)
  • Signs of blood problems: unusual infections, bruising or bleeding
  • Severe weakness or unusual muscle problems
  • Unusual movement or coordination problems

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Generally fewer interactions than many seizure medicines, but other sedating medicines can add to drowsiness
  • Alcohol (added drowsiness and effect on seizures)
  • Other seizure medicines (your clinician balances the combination)

Who should take care

  • Tell your clinician about any mood or behaviour changes, which can occur and may need attention
  • Tell your clinician if you are pregnant, planning pregnancy or breastfeeding
  • Use with caution and possible dose adjustment if you have kidney problems
  • Do not stop suddenly; reduce only under medical guidance
  • May affect driving until you know how it affects you

Frequently asked questions

Can levetiracetam affect mood or behaviour?
Yes, some people experience irritability, low mood, agitation or aggression. Tell your clinician if you notice mood or behaviour changes, as adjustments may help.
Does it have many drug interactions?
It has relatively few interactions compared with some older seizure medicines, which is one reason it is widely used. Still, always tell your clinician and pharmacist everything you take.
Why might my dose be lower if I have kidney problems?
Levetiracetam is mainly cleared by the kidneys, so reduced kidney function may mean a lower amount is needed to avoid build-up. Your clinician adjusts accordingly.
Can I stop it once my seizures are controlled?
Never stop suddenly. Stopping abruptly can trigger seizures. Any change must be planned and supervised by your clinician.
Is Levetiracetam safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

Related conditions

Related medicines

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