What it is used for
- Type 2 diabetes (to lower blood sugar when diet and other measures are not enough)
How it works
Glibenclamide stimulates the pancreas to release more of its own insulin, which lowers blood sugar. Because it actively pushes insulin out, it can cause blood sugar to drop too low if meals are missed.
How it is taken
Available as tablets taken by mouth, usually with or before a meal. Take it exactly as your doctor, pharmacist, or the label directs. Eating regular meals is important while on this medicine.
No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.
Common side effects
- Low blood sugar (hypoglycaemia) — shakiness, sweating, hunger, dizziness
- Weight gain
- Nausea or stomach upset
- Mild skin rash
Serious effects — get help
- Severe or prolonged low blood sugar causing confusion, seizures, or loss of consciousness — seek emergency care
- Signs of a serious allergic or skin reaction (widespread rash, blistering, swelling)
- Yellowing of the skin or eyes (possible liver problem)
If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.
Interactions to watch
- Other diabetes medicines and insulin (added risk of low blood sugar)
- Alcohol (can worsen low blood sugar and cause flushing)
- Some heart, blood-pressure, and infection medicines that affect blood sugar
- Certain antifungal and sulfonamide antibiotics
Who should take care
- Higher risk of low blood sugar in older adults and people with kidney or liver problems
- Tell your doctor if you skip meals, exercise heavily, or drink alcohol
- Generally avoided in pregnancy and breastfeeding unless a doctor advises otherwise
- Carry a fast-acting sugar source in case blood sugar drops