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Antiviral (nucleoside analogue prodrug)

Valganciclovir: uses, side effects & precautions

Also known as Valcyte, Valganciclovir.

This information is for general guidance only and does not constitute medical advice. Always consult a qualified healthcare professional for personal medical concerns. In an emergency, call your local emergency number.

What it is used for

  • Cytomegalovirus (CMV) infection, including CMV eye disease in people with weakened immunity
  • Prevention of CMV disease after organ transplantation

How it works

Valganciclovir is converted in the body into ganciclovir, which blocks the enzyme cytomegalovirus uses to copy its DNA, stopping the virus from multiplying. It is used in people at high risk of serious CMV disease, such as those with weakened immune systems or transplant recipients.

How it is taken

Available as tablets and an oral liquid/suspension. It is taken by mouth, usually with food, and the course can be long for prevention or treatment. Take it exactly as your specialist directs, do not crush or break the tablets, and attend the blood tests your clinician arranges to monitor for side effects.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Nausea
  • Diarrhoea
  • Headache
  • Tiredness
  • Fever
  • Reduced appetite

Serious effects — get help

  • Signs of low blood counts such as easy bruising, bleeding, frequent infections, severe tiredness, or breathlessness
  • Signs of kidney problems
  • Severe allergic reaction
  • Seizures, confusion, or tremors

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Other medicines that lower blood counts or affect the kidneys
  • Some HIV and antiviral medicines
  • Immunosuppressants used after transplant
  • Tell your clinician about every medicine you take, as monitoring is important

Who should take care

  • Regular blood tests are needed to check blood counts and kidney function
  • Tablets should be handled carefully and not broken or crushed
  • Effective contraception is usually advised during and for a period after treatment for both men and women
  • Use in pregnancy or breastfeeding is generally avoided unless essential

Frequently asked questions

Why do I need regular blood tests?
Valganciclovir can lower blood cell counts and affect the kidneys, so your clinician monitors these to keep treatment safe and adjust the dose if needed.
Why must I not crush the tablets?
The medicine can be harmful if powder is breathed in or touches skin or eyes. Handle tablets carefully and wash your hands; ask your pharmacist if a tablet breaks.
Can I take it during pregnancy?
It is generally avoided in pregnancy because of potential harm. Discuss contraception and any pregnancy plans with your specialist.
Is it the same as ganciclovir?
It turns into ganciclovir in the body but is taken by mouth, whereas ganciclovir is usually given by injection. Your specialist chooses based on your situation.
Is Valganciclovir safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

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