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Progestogen-only hormonal contraceptive

Progestogen-Only Pill: uses, side effects & precautions

Also known as POP, Mini-pill, Cerazette, Desogestrel, Norethisterone (contraceptive), Cerelle, Slynd.

This information is for general guidance only and does not constitute medical advice. Always consult a qualified healthcare professional for personal medical concerns. In an emergency, call your local emergency number.

What it is used for

  • Preventing pregnancy
  • Contraception when estrogen is not suitable (e.g. while breastfeeding, smokers over 35, or those at higher clot risk)

How it works

It contains only a progestogen hormone. Depending on the type, it thickens cervical mucus to block sperm, thins the womb lining, and may stop the ovaries releasing an egg.

How it is taken

Taken as a daily tablet, usually every day without a hormone-free break. Some types must be taken within a strict daily time window. Take it exactly as your doctor, pharmacist, or the label directs, and ask what to do if you take it late or miss a dose.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Irregular bleeding or spotting
  • Periods stopping altogether
  • Headache
  • Breast tenderness
  • Acne
  • Mood changes
  • Small ovarian cysts that usually clear on their own

Serious effects — get help

  • Severe lower abdominal pain (which can rarely signal an ectopic pregnancy)
  • Signs of a serious allergic reaction
  • Yellowing of skin or eyes
  • A new breast lump that needs prompt assessment

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Some epilepsy medicines
  • Certain HIV and hepatitis C medicines
  • Tuberculosis antibiotics (rifampicin-type)
  • St John's Wort
  • Other liver-enzyme-inducing medicines can reduce its reliability

Who should take care

  • Tell your clinician about any history of breast cancer, liver disease, or unexplained vaginal bleeding
  • Often suitable while breastfeeding, but confirm with your clinician
  • If a period is very late or you have severe one-sided abdominal pain, seek urgent assessment to rule out ectopic pregnancy
  • Does not protect against STIs

Frequently asked questions

How is it different from the combined pill?
It contains no estrogen, so it can be used by many people who cannot take combined hormones, such as some smokers over 35 or those who are breastfeeding.
What if I take it late?
Some mini-pills have only a short window of leeway, while newer ones allow more. Check your leaflet or ask a pharmacist; you may need extra precautions or emergency contraception.
Is it normal for my periods to stop?
Yes, periods often become irregular or stop while taking it, which is not harmful. Mention any sudden change to your clinician.
Does it cause weight gain?
Most people do not gain significant weight. Discuss any concerns with your clinician.
Is Progestogen-Only Pill safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

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