What it is used for
- Type 2 diabetes (to improve blood sugar control, alone or with other diabetes medicines)
How it works
Sitagliptin works by protecting natural gut hormones (incretins) that help the body release insulin after meals and reduce sugar made by the liver. This lowers blood sugar mainly when it is high, so on its own it rarely causes low blood sugar.
How it is taken
Available as tablets taken by mouth, usually once a day with or without food, and also in combination tablets with metformin. Take it exactly as your doctor, pharmacist, or the label directs.
No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.
Common side effects
- Headache
- Stuffy or runny nose and sore throat
- Upper respiratory infections
- Nausea or stomach upset
- Joint pain
Serious effects — get help
- Severe and persistent stomach pain that may spread to the back (possible pancreatitis) — seek urgent care
- Serious allergic or skin reactions (swelling of face/throat, blistering rash) — seek urgent care
- Signs of severe joint pain that is disabling
If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.
Interactions to watch
- Other diabetes medicines, especially sulfonylureas and insulin (added low-blood-sugar risk)
- Some medicines that affect the kidneys
- Generally fewer interactions than many older diabetes drugs, but always check with your pharmacist
Who should take care
- Dose may need lowering if you have reduced kidney function
- Tell your doctor about any history of pancreatitis
- Discuss pregnancy and breastfeeding with your clinician, as safety data are limited
- Report severe stomach pain or signs of an allergic reaction promptly