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Antidiabetic / GLP-1 receptor agonist

Dulaglutide: uses, side effects & precautions

Also known as Trulicity.

Diese Informationen dienen ausschließlich der allgemeinen Orientierung und stellen keine medizinische Beratung dar. Konsultieren Sie bei persönlichen gesundheitlichen Anliegen stets eine qualifizierte medizinische Fachkraft. Wählen Sie im Notfall Ihre örtliche Notrufnummer.

What it is used for

  • Type 2 diabetes (to improve blood sugar control)
  • Reducing cardiovascular risk in selected patients (on a doctor's advice)

How it works

Dulaglutide mimics the natural gut hormone GLP-1, helping the body release insulin after meals, lowering sugar made by the liver, slowing stomach emptying, and reducing appetite to lower blood sugar.

How it is taken

Given as a once-weekly injection under the skin using a pre-filled pen, with or without food. Use it exactly as your doctor or diabetes nurse shows you and as the label directs; rotate injection sites and never share pens or needles.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Nausea, especially when starting
  • Diarrhoea or vomiting
  • Reduced appetite
  • Indigestion or burping
  • Injection-site reactions

Serious effects — get help

  • Severe, persistent stomach pain possibly spreading to the back (possible pancreatitis) — seek urgent care
  • Gallbladder problems — seek care for upper-right abdominal pain, fever, or yellow skin
  • Serious allergic reaction
  • A neck lump, trouble swallowing, or persistent hoarseness (rare thyroid concern) — tell your doctor

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Insulin and sulfonylureas (added low-blood-sugar risk)
  • Slowed stomach emptying can affect absorption of some oral medicines
  • Alcohol (affects blood sugar)
  • Check all medicines with your pharmacist

Who should take care

  • Tell your doctor about any history of pancreatitis or medullary thyroid cancer / MEN 2
  • Start-up nausea usually eases over time; report severe symptoms
  • Stay hydrated with vomiting or diarrhoea
  • Generally avoided in pregnancy and breastfeeding unless advised
  • Report severe abdominal pain promptly

Frequently asked questions

How often do I take dulaglutide?
It is a once-weekly injection. Try to take it on the same day each week, with or without food, as the label directs.
What if I miss my weekly dose?
There is usually a window to take a missed dose, but follow your label and pharmacist's advice rather than guessing. Do not take two doses close together.
Does it cause low blood sugar?
On its own it rarely does; the risk increases with insulin or sulfonylureas.
Will it help with weight?
Many people lose some weight due to reduced appetite, though it is licensed for diabetes. Discuss weight goals with your care team.
Is Dulaglutide safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

Related conditions

Related medicines

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