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Long-acting progestogen-only contraceptive (injectable)

Medroxyprogesterone Acetate: uses, side effects & precautions

Also known as Depo-Provera, The injection, DMPA, Sayana Press, Depo shot.

Deze informatie is uitsluitend bedoeld als algemene richtlijn en vormt geen medisch advies. Raadpleeg altijd een gekwalificeerde zorgprofessional voor persoonlijke medische vragen. Bel in geval van nood uw lokale alarmnummer.

What it is used for

  • Long-term contraception
  • Managing heavy or painful periods (when prescribed)
  • Endometriosis-related pain (in certain formulations)

How it works

A progestogen hormone given by injection that stops the ovaries releasing an egg, thickens cervical mucus, and thins the womb lining.

How it is taken

Given as an injection at regular intervals by a healthcare professional, or in some places as a self-administered under-the-skin version. The timing of repeat doses matters, so keep to the schedule your clinician sets and follow their instructions exactly.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Irregular bleeding, then often lighter or no periods
  • Weight changes
  • Headache
  • Mood changes
  • Reduced libido
  • Delay in fertility returning after stopping (can take several months to over a year)

Serious effects — get help

  • Signs of a serious allergic reaction
  • Severe depression
  • Severe abdominal pain
  • Symptoms of a blood clot

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Generally fewer interactions than pills, but tell your clinician about all medicines
  • Some medicines for diabetes or other long-term conditions may need monitoring

Who should take care

  • Long-term use may lower bone density, which usually recovers after stopping; discuss this if you are young or have osteoporosis risk
  • Not ideal if you want to conceive in the near future, because fertility can take time to return
  • Tell your clinician about any history of breast cancer, liver disease, or unexplained vaginal bleeding
  • Does not protect against STIs

Frequently asked questions

How long does one injection last?
Each dose covers a set number of weeks, after which a repeat is needed. Your clinician will tell you when to return.
Why have my periods stopped?
Many people stop having periods on the injection, which is common and not harmful.
Will it affect my ability to get pregnant later?
Fertility usually returns but can take several months to over a year, so it may not suit you if you want to conceive soon.
Does it affect my bones?
Long-term use can reduce bone density, which generally recovers after stopping. Discuss your individual risk with your clinician.
Is Medroxyprogesterone Acetate safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

Related conditions

Related medicines

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