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Corticosteroid (glucocorticoid), potent anti-inflammatory and immunosuppressant

Dexamethasone: uses, side effects & precautions

Also known as Decadron, Dexsol, Ozurdex (eye implant), Maxidex (eye drops).

Deze informatie is uitsluitend bedoeld als algemene richtlijn en vormt geen medisch advies. Raadpleeg altijd een gekwalificeerde zorgprofessional voor persoonlijke medische vragen. Bel in geval van nood uw lokale alarmnummer.

What it is used for

  • Severe inflammation and swelling, including around tumours or in the brain
  • Severe allergic and autoimmune conditions
  • Certain severe respiratory illnesses, under medical supervision
  • Reducing nausea and inflammation in some cancer treatments; eye inflammation (drops)

How it works

Dexamethasone is a powerful corticosteroid that strongly suppresses inflammation and immune activity throughout the body, reducing swelling, redness and the harmful effects of an overactive immune response.

How it is taken

Available as tablets, oral solution, injection (hospital use), eye drops and other specialist forms. Take or use it exactly as your doctor or the label directs, usually with or after food for tablets. Do not stop it suddenly after more than a short course — your doctor will guide a gradual reduction.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Increased appetite and weight gain
  • Difficulty sleeping, restlessness or mood changes
  • Indigestion
  • Raised blood sugar and fluid retention

Serious effects — get help

  • Signs of serious infection (steroids can mask or worsen them)
  • Severe mood changes, confusion or psychosis
  • Stomach ulcer or bleeding
  • Adrenal crisis if stopped abruptly (severe weakness, dizziness, low blood pressure)
  • Vision changes or signs of dangerously high blood sugar

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • NSAIDs (increased stomach-bleeding risk)
  • Diabetes medicines (steroids raise blood sugar)
  • Live vaccines (generally avoided during treatment)
  • Some medicines that change how the steroid is processed
  • Blood thinners and medicines affecting potassium

Who should take care

  • Do not stop suddenly after prolonged use; follow a tapering plan to avoid adrenal crisis
  • Carry a steroid card and tell any healthcare professional you take it
  • Tell your doctor about diabetes, high blood pressure, infections, ulcers, glaucoma or mental health conditions
  • Avoid contact with chickenpox or measles if not immune, as infection can be severe
  • Seek urgent care for signs of serious infection or adrenal crisis

Frequently asked questions

How is dexamethasone different from prednisolone?
Both are corticosteroids, but dexamethasone is more potent and longer-acting. The choice depends on the condition being treated — your doctor decides.
Why must I taper off it?
Longer courses suppress the body's own steroid production, so stopping abruptly can cause a dangerous shortfall. The dose is reduced gradually as directed.
Does it affect blood sugar?
Yes, it can raise blood sugar, which matters especially if you have diabetes. Your doctor may monitor or adjust your diabetes treatment.
Can it affect mood and sleep?
It commonly causes difficulty sleeping, restlessness and mood changes, sometimes more pronounced than with milder steroids. Tell your doctor if these are severe.
Is Dexamethasone safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

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