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Anticonvulsant / nerve-pain medicine (gabapentinoid) - a controlled medicine in some regions

Pregabalin: uses, side effects & precautions

Also known as Lyrica.

Ces informations sont fournies à titre indicatif uniquement et ne constituent pas un avis médical. Consultez toujours un professionnel de santé qualifié pour toute préoccupation médicale personnelle. En cas d'urgence, appelez votre numéro d'urgence local.

What it is used for

  • Nerve (neuropathic) pain
  • Epilepsy (as an add-on for certain seizures)
  • Generalised anxiety disorder (in some regions)
  • Fibromyalgia (in some regions)

How it works

Pregabalin attaches to a part of nerve cells (calcium channels) that affects the release of signalling chemicals, which calms overactive nerve signals involved in pain, seizures and anxiety.

How it is taken

Usually available as capsules, tablets and an oral liquid. It is taken by mouth, with the amount usually increased gradually. Take it exactly as your doctor or pharmacist directs and follow the label; do not stop suddenly, as withdrawal effects can occur.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Drowsiness
  • Dizziness
  • Blurred vision
  • Weight gain
  • Dry mouth
  • Swelling of hands or feet
  • Difficulty concentrating
  • Unsteadiness

Serious effects — get help

  • Slowed or shallow breathing, especially with opioids or other sedatives (seek emergency help)
  • Mood changes or suicidal thoughts
  • Severe allergic reaction (swelling of face, lips or throat, trouble breathing)
  • Severe dizziness or fainting
  • Muscle pain or weakness with feeling unwell
  • Dependence and withdrawal symptoms if stopped abruptly

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Opioid painkillers (dangerous combined sedation and breathing suppression)
  • Alcohol and other sedatives (added drowsiness)
  • Other medicines that cause drowsiness
  • Medicines that cause fluid retention or swelling

Who should take care

  • Has potential for misuse and dependence; it is a controlled medicine in some regions
  • Do not combine with opioids or alcohol without specialist supervision because of breathing risk
  • Use with caution and possible dose adjustment with kidney problems
  • Tell your clinician if you are pregnant, planning pregnancy or breastfeeding
  • Do not stop suddenly; taper under medical guidance, and avoid driving if affected

Frequently asked questions

Why is pregabalin controlled in some countries?
It can be misused and can cause dependence, so some regions classify it as a controlled medicine. Take only as prescribed and store it safely.
Why is mixing it with opioids dangerous?
Combining pregabalin with opioid painkillers or other sedatives can dangerously slow breathing, especially in vulnerable people. Always tell your prescriber about all your medicines.
Can I stop it suddenly when my pain improves?
No. Stopping abruptly can cause withdrawal effects such as anxiety, trouble sleeping, sweating and nausea. Your clinician will guide a gradual reduction.
Will it make me gain weight?
Weight gain and swelling of the hands or feet can occur. Tell your clinician if these are a problem.
Is Pregabalin safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

Related conditions

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