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Antidiabetic / meglitinide (prandial insulin releaser)

Repaglinide: uses, side effects & precautions

Also known as Prandin, NovoNorm, Eurepa.

Esta información es solo orientativa de carácter general y no constituye un consejo médico. Consulta siempre a un profesional sanitario cualificado para cualquier asunto médico personal. En caso de emergencia, llama al número de emergencias de tu zona.

What it is used for

  • Type 2 diabetes (to control the rise in blood sugar around meals)

How it works

Repaglinide prompts the pancreas to release a quick burst of insulin around mealtimes, helping control the rise in blood sugar after eating. It works fast and for a short time.

How it is taken

Available as tablets taken by mouth shortly before meals. A key rule is: take it with a meal, skip it if you skip the meal. Take it exactly as your doctor, pharmacist, or the label directs.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Low blood sugar (hypoglycaemia)
  • Weight gain
  • Headache
  • Stomach upset or diarrhoea

Serious effects — get help

  • Severe low blood sugar with confusion, seizures, or unconsciousness — seek emergency care
  • Signs of liver problems (yellow skin or eyes, dark urine)
  • Serious allergic reaction (uncommon)

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Other diabetes medicines and insulin (added low-blood-sugar risk)
  • Some medicines that affect liver enzymes (certain antibiotics, antifungals, and others) can raise or lower its effect
  • Gemfibrozil (a cholesterol medicine) should not be combined with it
  • Alcohol (worsens low blood sugar)

Who should take care

  • Because it acts around meals, do not take a dose if you are skipping that meal
  • Use with caution in liver problems
  • Carry a fast-acting sugar source for low blood sugar
  • Discuss pregnancy and breastfeeding with your clinician
  • Tell your doctor about all other medicines, as several interact

Frequently asked questions

What is the main rule for taking repaglinide?
One meal, one dose; no meal, no dose. Because it triggers a quick burst of insulin around eating, taking it without food can cause low blood sugar.
How is it different from sulfonylureas?
Both make the pancreas release insulin, but repaglinide acts faster and for a shorter time, giving more flexibility around meals. Your doctor chooses the best fit.
Does it cause low blood sugar?
Yes, it can, especially if a meal is missed or delayed. Keep a fast-acting sugar source handy.
Which medicines should not be combined with it?
Gemfibrozil should not be taken with repaglinide, and several other medicines can affect it. Always check with your pharmacist.
Is Repaglinide safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

Related conditions

Related medicines

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