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Antidiabetic / DPP-4 inhibitor (gliptin)

Linagliptin: uses, side effects & precautions

Also known as Trajenta, Tradjenta, Jentadueto (with metformin).

Esta información es solo orientativa de carácter general y no constituye un consejo médico. Consulta siempre a un profesional sanitario cualificado para cualquier asunto médico personal. En caso de emergencia, llama al número de emergencias de tu zona.

What it is used for

  • Type 2 diabetes (to improve blood sugar control, alone or with other medicines)

How it works

Linagliptin protects natural gut hormones that prompt the body to release insulin after eating and reduce sugar produced by the liver, lowering blood sugar mainly when it is high.

How it is taken

Available as tablets taken by mouth, usually once a day with or without food, and in combination tablets with metformin. Take it exactly as your doctor, pharmacist, or the label directs.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Stuffy or runny nose, sore throat
  • Cough
  • Mild stomach upset
  • Raised blood fat levels in some people

Serious effects — get help

  • Severe, persistent stomach pain possibly spreading to the back (possible pancreatitis) — seek urgent care
  • Serious allergic or skin reactions including swelling of face or throat — seek urgent care
  • Severe blistering skin reactions

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Other diabetes medicines, especially sulfonylureas and insulin (added low-blood-sugar risk)
  • Certain medicines that affect liver enzymes (such as some seizure or tuberculosis drugs) may reduce its effect
  • Check all medicines with your pharmacist

Who should take care

  • Often a useful option for people with reduced kidney function, but use is still guided by your doctor
  • Tell your doctor about any history of pancreatitis
  • Discuss pregnancy and breastfeeding with your clinician, as data are limited
  • Report severe stomach pain or allergic symptoms promptly

Frequently asked questions

Is linagliptin good if I have kidney problems?
Linagliptin is largely cleared by the body without relying heavily on the kidneys, so it is often used without dose changes in kidney impairment — but your doctor still decides.
Does it cause low blood sugar?
On its own, rarely. The risk increases when combined with sulfonylureas or insulin.
Can it be combined with metformin?
Yes, it is commonly used with metformin and available as a combined tablet.
Does it affect my weight?
It is generally weight-neutral. Lifestyle measures remain important for overall control.
Is Linagliptin safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

Related conditions

Related medicines

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