Skip to content

Mucosal protectant (ulcer-coating agent)

Sucralfate: uses, side effects & precautions

Also known as Carafate, Antepsin.

This information is for general guidance only and does not constitute medical advice. Always consult a qualified healthcare professional for personal medical concerns. In an emergency, call your local emergency number.

What it is used for

  • Stomach and duodenal ulcers
  • Protecting and helping heal irritated or ulcerated areas in the upper gut
  • Preventing stress-related ulcers in some hospital settings

How it works

Sucralfate forms a protective layer over ulcers and damaged areas of the stomach or gut lining, shielding them from acid and enzymes so they can heal. It works mainly on contact rather than by reducing acid.

How it is taken

Comes as tablets and an oral suspension. It is taken by mouth, usually on an empty stomach. Take it exactly as your doctor, pharmacist, or the label directs, and separate it in time from other medicines and antacids.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Constipation
  • Dry mouth
  • Nausea
  • Indigestion

Serious effects — get help

  • Severe constipation or signs of a bowel blockage
  • Signs of aluminium build-up in people with kidney failure (confusion, bone pain)
  • Severe allergic reaction

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Can reduce absorption of many medicines (some antibiotics, thyroid medicine, certain heart and seizure drugs) — separate timing
  • Antacids reduce its effect if taken at the same time

Who should take care

  • Tell your clinician about kidney problems, as it contains aluminium
  • Separate it from other medicines, usually by a couple of hours
  • Take it on an empty stomach for best effect, as directed
  • Discuss pregnancy and breastfeeding with a pharmacist
  • Seek assessment for ongoing or alarm symptoms

Frequently asked questions

How is sucralfate different from a PPI?
It physically coats and protects ulcers rather than reducing acid. Sometimes both approaches are used together under guidance.
When should I take it?
Usually on an empty stomach and separated from other medicines and meals. Follow your exact instructions.
Does it interact with my other tablets?
It can reduce how well some are absorbed. Take other medicines a couple of hours apart and ask your pharmacist.
Is it safe with kidney problems?
It contains aluminium, so people with significant kidney disease need caution. Tell your clinician.

Related conditions

Related medicines

See a doctor online now