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Long-acting beta-2 agonist (LABA) bronchodilator

Salmeterol: uses, side effects & precautions

Also known as Serevent, Seretide (with fluticasone), Advair (with fluticasone).

This information is for general guidance only and does not constitute medical advice. Always consult a qualified healthcare professional for personal medical concerns. In an emergency, call your local emergency number.

What it is used for

  • Asthma (long-term control, always alongside a steroid preventer)
  • Chronic obstructive pulmonary disease (COPD)
  • Preventing ongoing wheeze and breathlessness
  • Helping keep airways open through the day and night

How it works

Salmeterol relaxes the muscles around the airways and keeps them open for a long period. It is taken regularly to prevent symptoms, not to relieve a sudden attack.

How it is taken

Used as an inhaler, often combined with an inhaled steroid in a single device. It is breathed in and taken regularly. In asthma it must always be used together with a steroid preventer, never on its own. Use it exactly as your clinician directs.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Shakiness or trembling
  • Fast or pounding heartbeat
  • Headache
  • Muscle cramps
  • Throat irritation

Serious effects — get help

  • Worsening breathing or wheeze despite regular use (seek urgent review)
  • Chest pain or a very fast/irregular heartbeat
  • Sudden wheeze or breathing difficulty straight after use (seek emergency help)
  • Signs of a severe allergic reaction

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Beta-blockers (can oppose its effect and worsen breathing)
  • Some diuretics and other asthma medicines (may affect potassium)
  • Certain antifungal/HIV medicines and some antidepressants

Who should take care

  • In asthma, never use salmeterol without a steroid preventer
  • It is not a reliever — always keep a fast-acting reliever for sudden symptoms
  • Caution with heart conditions, high blood pressure, an overactive thyroid, or diabetes
  • Tell your clinician if you are pregnant, planning pregnancy, or breastfeeding

Frequently asked questions

Can I use salmeterol for a sudden asthma attack?
No — it is long-acting and works slowly to prevent symptoms. Always use your fast-acting reliever for sudden attacks.
Why must it be used with a steroid in asthma?
Used alone in asthma, long-acting bronchodilators can be unsafe. They are always combined with a steroid preventer, often in one inhaler.
How is it different from salbutamol?
Salbutamol is a fast, short-acting reliever; salmeterol is long-acting and taken regularly for ongoing control.
What if my breathing is getting worse?
Tell your clinician promptly. Needing more relief or feeling worse despite regular use means your condition may not be well controlled.
Is Salmeterol safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

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