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Antiparasitic and antibacterial (aminoglycoside)

Paromomycin: uses, side effects & precautions

Also known as Humatin.

This information is for general guidance only and does not constitute medical advice. Always consult a qualified healthcare professional for personal medical concerns. In an emergency, call your local emergency number.

What it is used for

  • Intestinal amoebiasis (clearing amoebae from the gut)
  • Giardiasis
  • Some tapeworm infections
  • Leishmaniasis in certain forms and regions

How it works

Paromomycin interferes with the parasite's ability to make the proteins it needs to live. Taken by mouth it mostly stays in the gut, which makes it useful for clearing intestinal parasites.

How it is taken

Taken as oral capsules for intestinal infections, usually with food, as a short course; an injectable form is used for leishmaniasis in some settings. Because little is absorbed from the gut, the oral form acts mainly within the intestine. Take it exactly as your doctor or pharmacist directs.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Stomach upset or cramps
  • Nausea
  • Diarrhea
  • Heartburn
  • Loss of appetite

Serious effects — get help

  • Hearing changes, ringing in the ears, or dizziness (more relevant with the injectable form or in bowel disease) — contact your clinician
  • Signs of kidney problems such as reduced urine — contact your clinician
  • Severe or bloody diarrhea — seek care
  • Severe allergic reaction — seek emergency care

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Other medicines that can affect hearing or the kidneys (especially relevant with absorption)
  • Some muscle-relaxing medicines used in surgery

Who should take care

  • Tell your clinician about bowel disease or ulcers, which can increase how much is absorbed
  • Report kidney problems or hearing issues
  • Inform your clinician if pregnant or breastfeeding
  • Take with food to reduce stomach upset
  • Complete the full course

Frequently asked questions

Why does it mostly stay in my gut?
Very little of the oral form is absorbed into the bloodstream, so it concentrates in the intestine, which is exactly where it is needed for gut parasites.
Is it used after another amoeba medicine?
For amoebiasis it is sometimes used to clear remaining parasites from the gut after the main infection is treated. Your clinician will set the plan.
Should I worry about my hearing?
Hearing effects are uncommon with the gut-acting oral form but more relevant if more is absorbed or with the injection. Report any hearing changes or ringing in the ears.
Can I take it in pregnancy?
Discuss it with your clinician, who will weigh the benefits and risks. Tell them if you are or might be pregnant.
Is Paromomycin safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

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