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Antibiotic (tetracycline)

Minocycline: uses, side effects & precautions

Also known as Minocin, Solodyn, Aknemin.

This information is for general guidance only and does not constitute medical advice. Always consult a qualified healthcare professional for personal medical concerns. In an emergency, call your local emergency number.

What it is used for

  • Moderate to severe acne
  • Rosacea
  • Some respiratory and skin infections
  • Certain other specialised infections

How it works

Minocycline is a tetracycline antibiotic. It stops bacteria from making the proteins they need to grow and reduces inflammation, which is why it is often used for acne. It does not work against viruses.

How it is taken

Comes as capsules and tablets, including modified-release forms, and as a foam or gel for the skin in some regions. Take or use it exactly as your doctor or pharmacist directs and follow the label. Take capsules with a full glass of water and stay upright afterwards. Complete the course as advised.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Nausea
  • Dizziness or a spinning sensation
  • Stomach upset
  • Increased sensitivity to sunlight
  • Headache
  • Thrush

Serious effects — get help

  • Severe allergic reaction with swelling or breathing difficulty
  • Severe headache with blurred vision (rare pressure around the brain)
  • Blue-grey discolouration of the skin, gums or nails with long use
  • A drug reaction with fever, rash and organ involvement (seek urgent care)
  • Yellowing of the skin or eyes
  • Joint pain with rash (a rare lupus-like reaction)

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Antacids and supplements with calcium, iron, magnesium or zinc (separate the timing)
  • Dairy products
  • Blood thinners such as warfarin
  • Oral retinoid acne medicines (avoid combining)
  • Penicillin-type antibiotics

Who should take care

  • Not usually given in pregnancy, breastfeeding or to young children as it can affect developing teeth and bones
  • Long-term use can occasionally cause skin or gum discolouration
  • Use sun protection as skin can burn more easily
  • Tell your clinician if you develop dizziness, which can affect driving
  • Report fever with rash, which can signal a serious reaction

Frequently asked questions

Why is minocycline often used for acne?
It reduces acne-causing bacteria and calms inflammation. Acne treatments take several weeks to work, so use it consistently as directed.
Can it make me dizzy?
Some people feel dizzy or lightheaded, especially at first. Take care with driving until you know how it affects you, and tell your pharmacist if it persists.
What is the blue-grey skin change?
With long-term use, minocycline can rarely cause blue-grey discolouration of the skin, gums or nails. Tell your clinician if you notice this.
Will it make me sensitive to the sun?
Yes, use sun protection and avoid strong sun and sunbeds while taking it.
Is Minocycline safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

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