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Nonsteroidal anti-inflammatory drug (NSAID)

Ketoprofen: uses, side effects & precautions

Also known as Orudis, Oruvail, Ketoflam.

This information is for general guidance only and does not constitute medical advice. Always consult a qualified healthcare professional for personal medical concerns. In an emergency, call your local emergency number.

What it is used for

  • Pain and inflammation from arthritis
  • Muscle and joint pain, sprains and strains
  • Back pain
  • Period pain
  • Pain after minor injuries

How it works

Ketoprofen blocks the COX enzymes that make prostaglandins, reducing pain, swelling and inflammation in affected tissues.

How it is taken

Available as capsules and tablets (including modified-release), gels for the skin, and suppositories. Take or apply it exactly as your doctor, pharmacist or the label directs. Oral forms are usually taken with or after food. The topical gel can make skin more sensitive to sunlight, so protect treated areas from sun.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Indigestion, heartburn or stomach discomfort
  • Nausea
  • Headache or dizziness
  • Skin reactions with the gel, including sun sensitivity

Serious effects — get help

  • Stomach or gut bleeding or ulcers (black stools, vomiting blood, severe abdominal pain)
  • Heart attack or stroke warning signs
  • Serious allergic reaction or asthma flare (swelling, wheezing, difficulty breathing)
  • Severe skin reactions, including from sun exposure with the gel
  • Signs of kidney problems

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Other NSAIDs and aspirin
  • Blood thinners and antiplatelet drugs
  • Some blood pressure medicines and diuretics
  • Corticosteroids and SSRIs (bleeding risk)
  • Lithium and methotrexate
  • Alcohol

Who should take care

  • Avoided in late pregnancy; use only on clinician advice otherwise
  • Protect skin treated with the gel from sunlight and sunbeds during and after use
  • Tell your doctor about ulcers, asthma, heart disease, high blood pressure, or kidney or liver problems
  • Use the lowest effective amount for the shortest time
  • Seek urgent care for signs of gut bleeding or allergic reaction

Frequently asked questions

Why does the gel cause sun sensitivity?
Ketoprofen on the skin can react with sunlight and cause rashes or burns. Keep treated areas covered and out of the sun during use and for some time after, as directed.
Is ketoprofen stronger than ibuprofen?
It is a potent NSAID, but the best choice depends on your condition, other medicines and risk factors. Ask your pharmacist or doctor.
Can I take it with food?
Oral forms are usually taken with or after food to reduce stomach upset. Follow your specific product's directions.
Can I use the gel and capsules together?
Using oral and topical NSAIDs together adds to the total dose. Check with your pharmacist before combining forms.
Is Ketoprofen safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

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