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Antimalarial (artemisinin derivative)

Artesunate: uses, side effects & precautions

Also known as Artesun.

This information is for general guidance only and does not constitute medical advice. Always consult a qualified healthcare professional for personal medical concerns. In an emergency, call your local emergency number.

What it is used for

  • Treatment of severe malaria, including malaria affecting the brain or other organs
  • Initial treatment of severe malaria before switching to an oral antimalarial course

How it works

Artesunate is a fast-acting artemisinin medicine that rapidly reduces the number of malaria parasites in the blood, which is critical in severe, life-threatening malaria.

How it is taken

Given by injection into a vein or muscle in a hospital or clinical setting for severe malaria, then usually followed by a full oral antimalarial course once the person can take medicine by mouth. It is administered and monitored by healthcare professionals exactly as the treating team directs.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Nausea
  • Vomiting
  • Dizziness
  • Headache
  • Temporary changes in blood counts

Serious effects — get help

  • Delayed breakdown of red blood cells (a form of anemia) that can appear days to weeks after treatment, causing tiredness, pale skin, dark urine, or breathlessness — seek urgent care
  • Signs of a severe allergic reaction such as facial swelling or breathing difficulty — seek emergency care
  • Worsening confusion, seizures, or unconsciousness — emergency care

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Other medicines that affect heart rhythm
  • Other antimalarials given in sequence
  • Drugs that affect liver enzymes

Who should take care

  • Used and monitored in a healthcare setting because severe malaria is a medical emergency
  • Follow-up blood tests may be needed after treatment to check for delayed anemia
  • Tell the treating team if you are pregnant or breastfeeding
  • Report any history of blood disorders, liver, or kidney problems

Frequently asked questions

Why is this given by injection instead of tablets?
Severe malaria is an emergency where the medicine needs to act quickly throughout the body, so it is given by injection in a hospital and is then usually followed by an oral course.
Why might I need a blood test weeks later?
Some people develop delayed red-blood-cell breakdown after treatment. A follow-up blood test helps your clinician catch and manage this early. Attend any follow-up your team arranges.
Can I be treated for severe malaria at home?
No. Severe malaria needs urgent hospital care. If you suspect severe malaria, seek emergency medical help immediately.
Is it safe in pregnancy?
In severe malaria the risks of untreated illness are very high, so clinicians weigh this carefully. The treating team decides what is safest for you and your baby.

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