Skip to content

H2-receptor antagonist (acid-reducer)

Ranitidine: uses, side effects & precautions

Also known as Zantac (historic).

Deze informatie is uitsluitend bedoeld als algemene richtlijn en vormt geen medisch advies. Raadpleeg altijd een gekwalificeerde zorgprofessional voor persoonlijke medische vragen. Bel in geval van nood uw lokale alarmnummer.

What it is used for

  • Heartburn and indigestion (historically)
  • Acid reflux (GERD)
  • Stomach and duodenal ulcers

How it works

Ranitidine blocks histamine signals (at H2 receptors) that tell the stomach to make acid, so it lowers acid production and eases acid-related symptoms.

How it is taken

Was available as tablets, effervescent tablets, oral liquid, and injection. Importantly, many regulators (including in the US, UK, EU and elsewhere) withdrew or suspended ranitidine products after an impurity concern, so it is no longer widely available; alternatives are usually recommended. If you have old supplies, do not use them without checking with a pharmacist, and follow only current professional advice.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Headache
  • Constipation or diarrhea
  • Dizziness
  • Stomach discomfort

Serious effects — get help

  • Severe allergic reaction (swelling, breathing trouble)
  • Yellowing of skin or eyes (possible liver effect)
  • Confusion or fast/irregular heartbeat
  • Unusual bruising or bleeding

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Drugs needing stomach acid for absorption (some antifungals)
  • Warfarin
  • Certain other medicines whose levels depend on stomach acidity

Who should take care

  • Because of the withdrawal, ask a pharmacist about a suitable alternative such as another H2 blocker or a PPI
  • Tell your clinician about kidney or liver problems
  • Discuss pregnancy or breastfeeding before using any acid medicine
  • Do not self-treat persistent or alarm symptoms; get them assessed

Frequently asked questions

Why was ranitidine taken off the market?
Regulators found that some ranitidine products could contain an impurity (NDMA) above acceptable limits, leading to widespread withdrawal. Speak to a pharmacist about replacements.
What can I use instead?
Other H2 blockers like famotidine, or proton pump inhibitors, are common alternatives. A pharmacist or doctor can advise what suits you.
I still have old ranitidine. Can I take it?
Do not use withdrawn products without checking. Bring them to a pharmacy for advice or safe disposal.
Is famotidine the same thing?
It is a different drug in the same class and is still available in many countries. Ask your pharmacist.
Is Ranitidine safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

Related conditions

Related medicines

See a doctor online now