What it is used for
- High blood pressure (hypertension)
- Heart failure
- Protecting the heart after a heart attack
- Protecting the kidneys in some people with diabetes
How it works
Lisinopril blocks an enzyme that makes a hormone (angiotensin II) that narrows blood vessels. With less of this hormone, blood vessels relax and widen, lowering blood pressure and reducing the workload on the heart.
How it is taken
Taken by mouth as a tablet, and as an oral liquid in some countries, usually once a day with or without food. Take it exactly as your doctor or pharmacist directs and follow the label. Do not stop on your own; your clinician may want blood tests to check your kidneys and potassium during treatment.
No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.
Common side effects
- Dry, tickly cough
- Dizziness, especially when standing up
- Headache
- Tiredness
- Mild rise in blood potassium
Serious effects — get help
- Swelling of the face, lips, tongue or throat, or difficulty breathing or swallowing (angioedema) — seek emergency care
- Fainting
- Signs of high potassium such as muscle weakness or irregular heartbeat
- Reduced urination or signs of kidney problems
- Yellowing of the skin or eyes
If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.
Interactions to watch
- Potassium supplements and potassium-containing salt substitutes
- Potassium-sparing diuretics (e.g. spironolactone)
- Other blood pressure medicines, especially ARBs (avoid combining without advice)
- Non-steroidal anti-inflammatory drugs such as ibuprofen
- Lithium
- Some diabetes medicines (blood sugar may change)
Who should take care
- Do NOT use in pregnancy — it can harm the unborn baby; tell your doctor right away if you become or plan to become pregnant
- Tell your clinician about kidney disease or narrowing of the kidney arteries
- Avoid potassium-based salt substitutes unless advised
- Risk of dizziness is higher if dehydrated, on a low-salt diet, or also taking a water pill
- Mention any history of angioedema