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Antifungal (imidazole)

Clotrimazole: uses, side effects & precautions

Also known as Canesten, Lotrimin, Clotrimazole.

Deze informatie is uitsluitend bedoeld als algemene richtlijn en vormt geen medisch advies. Raadpleeg altijd een gekwalificeerde zorgprofessional voor persoonlijke medische vragen. Bel in geval van nood uw lokale alarmnummer.

What it is used for

  • Vaginal thrush (vaginal yeast infection)
  • Athlete's foot
  • Ringworm and jock itch
  • Other skin yeast and fungal infections
  • Fungal nappy or skin-fold rashes

How it works

Clotrimazole damages the membrane around fungal cells by blocking the production of a key building block (ergosterol). This stops the fungus growing and clears the infection. It is applied directly to the affected area rather than taken by mouth.

How it is taken

Widely available over the counter as a skin cream, vaginal cream, and vaginal pessary/tablet, plus solutions and powders. Apply to the affected skin or use the vaginal product exactly as the label, pharmacist, or doctor directs, and continue for the full recommended time even after symptoms ease to prevent the infection returning.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Mild burning, stinging, or itching where applied
  • Redness or irritation of the skin
  • Mild vaginal irritation with the internal forms

Serious effects — get help

  • Severe local reaction such as blistering, swelling, or worsening rash
  • Signs of an allergic reaction (widespread rash, swelling of face or throat, difficulty breathing)
  • Lower tummy pain, fever, or foul-smelling discharge when treating vaginal thrush (may signal a different infection)

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Latex condoms and diaphragms may be weakened by the vaginal cream or pessary, reducing protection
  • Few other significant interactions because little is absorbed into the body
  • Tell your pharmacist about other vaginal or skin products you use

Who should take care

  • Use extra contraception precautions, as latex products may be damaged by vaginal forms
  • See a clinician if it is your first episode of vaginal thrush or symptoms keep returning
  • Use in pregnancy on the advice of a clinician, who may prefer the pessary without an applicator
  • Avoid contact with the eyes

Frequently asked questions

How long does clotrimazole take to work for thrush?
Itching often eases within a few days, but use the full course to clear the infection. See your clinician if symptoms do not improve.
Can I use it with condoms?
Vaginal clotrimazole can weaken latex condoms and diaphragms for several days, so use extra non-latex protection. Ask your pharmacist for details.
Is it safe in pregnancy?
It is often used for thrush in pregnancy, usually as a pessary inserted by hand rather than with an applicator. Check with your doctor or midwife first.
Should I keep using it after symptoms go?
Yes, complete the recommended course so the infection clears fully and is less likely to return.

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