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Leukotriene receptor antagonist (asthma preventer / anti-inflammatory)

Montelukast: uses, side effects & precautions

Also known as Singulair.

Ces informations sont fournies à titre indicatif uniquement et ne constituent pas un avis médical. Consultez toujours un professionnel de santé qualifié pour toute préoccupation médicale personnelle. En cas d'urgence, appelez votre numéro d'urgence local.

What it is used for

  • Asthma (regular prevention, often alongside an inhaler)
  • Preventing exercise-induced asthma symptoms
  • Hay fever and allergic rhinitis (sometimes, especially with asthma)
  • Reducing the frequency of asthma attacks

How it works

Montelukast blocks leukotrienes, chemicals the body releases that cause airway swelling, tightening, and mucus. By blocking them, it helps keep the airways open and reduces asthma and allergy symptoms.

How it is taken

Comes as tablets, chewable tablets, and granules (for young children). It is taken by mouth, often in the evening. It is a preventer taken regularly, not for sudden relief. Take it exactly as your doctor or pharmacist directs and as the label says.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Headache
  • Stomach pain or upset
  • Cold-like symptoms or sore throat
  • Diarrhoea
  • Feeling thirsty

Serious effects — get help

  • Mental health or mood changes — including agitation, anxiety, depression, sleep problems, unusual dreams, or thoughts of self-harm (seek urgent advice)
  • Signs of a severe allergic reaction
  • Numbness, tingling, or flu-like symptoms with rash (rare)
  • Worsening breathing or wheeze

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Certain medicines for epilepsy (e.g. phenobarbital) and some others that affect liver enzymes
  • Tell your clinician about all your medicines, including other asthma treatments

Who should take care

  • Be aware of the risk of mood and behaviour changes — report any new mental health symptoms to a clinician promptly
  • Tell your clinician if you are pregnant, planning pregnancy, or breastfeeding
  • It does not relieve a sudden asthma attack — always keep a reliever inhaler
  • Tell your clinician about a history of mental health conditions before starting

Frequently asked questions

Can montelukast affect mood or mental health?
Yes. It has been linked to mood and behaviour changes, including anxiety, low mood, sleep disturbance, and rarely thoughts of self-harm. Report any such symptoms to a clinician straight away.
Is montelukast a reliever for asthma attacks?
No — it is a preventer taken regularly. It will not stop a sudden attack, so you still need a reliever inhaler.
Why is it often taken in the evening?
Evening dosing is commonly recommended, partly because asthma symptoms often worsen overnight. Follow your clinician's instructions.
Can children take montelukast?
Yes, there are forms made for children, but it should be used under a clinician's guidance, who will also discuss the mood-related cautions.
Is Montelukast safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

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