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Antiplatelet agent (blood thinner)

Dipyridamole: uses, side effects & precautions

Also known as Persantine, Persantin, Asasantin (with aspirin).

Ces informations sont fournies à titre indicatif uniquement et ne constituent pas un avis médical. Consultez toujours un professionnel de santé qualifié pour toute préoccupation médicale personnelle. En cas d'urgence, appelez votre numéro d'urgence local.

What it is used for

  • Helping prevent strokes and 'mini-strokes' (TIAs), often combined with low-dose aspirin
  • Reducing clot risk in some people, including after certain heart-valve surgery
  • Sometimes used in a heart-imaging test under supervision

How it works

Dipyridamole reduces the tendency of platelets to clump and also helps widen blood vessels. Together these effects lower the chance of clots forming, particularly in the small vessels of the brain.

How it is taken

Usually supplied as oral tablets or modified-release capsules, sometimes combined with aspirin in one product. It is generally taken one to a few times a day; modified-release forms are swallowed whole. Take it exactly as your doctor or pharmacist directs and as written on the label.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Headache (common when first starting, often eases)
  • Dizziness
  • Flushing
  • Tummy upset, nausea or diarrhoea
  • Muscle aches

Serious effects — get help

  • Heavy or unusual bleeding, black/tarry stools, blood in urine - seek urgent care
  • Chest pain or worsening angina
  • Fast or irregular heartbeat
  • Serious allergic reaction: facial or throat swelling, trouble breathing, severe rash

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Other blood thinners and antiplatelets (raises bleeding risk)
  • Anti-inflammatory painkillers (NSAIDs)
  • Adenosine (used in some heart tests)
  • Certain blood-pressure medicines (may add to blood-pressure lowering)
  • Some medicines for myasthenia gravis

Who should take care

  • Tell your clinician about angina, recent heart attack or low blood pressure
  • Headaches at the start are common - ask your pharmacist how to manage them rather than stopping
  • Report any bleeding problems
  • Tell any doctor, dentist or surgeon you take it before procedures
  • Discuss pregnancy or breastfeeding with your clinician

Frequently asked questions

Why does dipyridamole give me a headache?
Headaches are common in the first days because the medicine widens blood vessels. They usually settle - your pharmacist can advise on simple relief. Tell your clinician if they are severe.
Is it usually taken with aspirin?
For stroke prevention it is often combined with low-dose aspirin, sometimes in a single product, for stronger protection. Take it exactly as prescribed.
Can I crush the capsules?
Modified-release capsules should be swallowed whole so the medicine releases slowly. Ask your pharmacist if you have trouble swallowing.
Will it make me bleed more easily?
As a blood thinner it can increase bruising and bleeding. Heavy or unusual bleeding needs urgent care.
Is Dipyridamole safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

Related conditions

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