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Topical nasal decongestant (sympathomimetic)

Xylometazoline: uses, side effects & precautions

Also known as Otrivin, Otrivine, Sudafed nasal spray (some formulations).

Esta información es solo orientativa de carácter general y no constituye un consejo médico. Consulta siempre a un profesional sanitario cualificado para cualquier asunto médico personal. En caso de emergencia, llama al número de emergencias de tu zona.

What it is used for

  • Short-term relief of a blocked or stuffy nose
  • Nasal congestion from colds, flu, or hay fever
  • Sinus congestion
  • Easing breathing through the nose for a few days

How it works

Xylometazoline narrows the blood vessels in the lining of the nose, which reduces swelling and quickly clears a blocked nose so you can breathe more easily.

How it is taken

Comes as a nasal spray or drops applied directly into the nose. It is intended only for short-term use, usually no more than a few days, because longer use can cause rebound congestion. Use it exactly as your pharmacist or the label directs, and do not exceed the recommended duration.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Stinging, burning, or dryness in the nose
  • Sneezing
  • A blocked nose returning worse after stopping (rebound congestion) with overuse
  • Headache

Serious effects — get help

  • Fast or irregular heartbeat
  • Severe headache or raised blood pressure
  • Signs of a severe allergic reaction
  • Worsening congestion despite continued use

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Some antidepressants (MAOIs in particular)
  • Other decongestants
  • Medicines for blood pressure or the heart (tell your pharmacist)

Who should take care

  • Do not use for longer than the recommended few days, to avoid rebound congestion
  • Caution with high blood pressure, heart disease, an overactive thyroid, diabetes, or an enlarged prostate
  • Tell your clinician if you are pregnant, planning pregnancy, or breastfeeding
  • Do not share the spray or drops, to avoid spreading infection

Frequently asked questions

Why can't I use it for more than a few days?
Using it too long can cause rebound congestion, where your nose becomes more blocked once you stop. Limit it to the short period stated on the label.
What is rebound congestion?
It is a worsening of a blocked nose that can happen after overusing decongestant sprays, making you feel you need them even more.
Is it safe with high blood pressure?
Use it cautiously and check with a pharmacist first, as decongestants can raise blood pressure and heart rate.
Can I use it for hay fever?
It can relieve a blocked nose short-term, but steroid or antihistamine sprays are better for ongoing allergy symptoms. Ask a pharmacist for advice.

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