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Progestogen (synthetic progesterone-like hormone)

Norethisterone: uses, side effects & precautions

Also known as Primolut N, Utovlan, Aygestin, norethindrone, norethisterone acetate.

Esta información es solo orientativa de carácter general y no constituye un consejo médico. Consulta siempre a un profesional sanitario cualificado para cualquier asunto médico personal. En caso de emergencia, llama al número de emergencias de tu zona.

What it is used for

  • Delaying a period
  • Heavy or painful periods
  • Irregular menstrual bleeding
  • Some symptoms of endometriosis
  • As part of certain hormone therapy or contraception

How it works

It is a progestogen that acts on the womb lining and menstrual cycle. Depending on the use, it can hold off a period, control bleeding, or ease menstrual symptoms.

How it is taken

Taken as a tablet, with timing that depends on the reason for use (for example starting a few days before an expected period to delay it). Take it exactly as your doctor or pharmacist directs.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Nausea
  • Headache
  • Breast tenderness
  • Bloating
  • Mood changes
  • Spotting or changes in bleeding
  • Reduced libido

Serious effects — get help

  • Signs of a blood clot (painful swollen calf, sudden breathlessness, chest pain)
  • Signs of a stroke
  • Severe migraine with vision changes
  • Yellowing of the skin or eyes

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Liver-enzyme-inducing medicines (some epilepsy and TB drugs, St John's Wort)
  • Some HIV and hepatitis C medicines
  • Tell your clinician about all medicines

Who should take care

  • Standard contraceptive-dose use carries clot considerations; tell your clinician about clot history, smoking, migraines, or liver disease
  • Not for use in pregnancy
  • When used only to delay a period it is not a reliable contraceptive at those doses, so do not rely on it to prevent pregnancy
  • Seek urgent help for clot or stroke symptoms

Frequently asked questions

Can it delay my period for a holiday or event?
Yes, it is commonly used short term to delay a period. Start it before your period is due, exactly as directed by your clinician or pharmacist.
Does it work as contraception?
At the doses used to delay periods it is not a reliable contraceptive, so keep using your usual contraception.
When will my period come after stopping?
Your period usually starts within a few days of stopping the tablets.
Can it help heavy periods?
Yes, it is sometimes prescribed to control heavy or irregular bleeding. Your clinician will set the right schedule.
Is Norethisterone safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

Related conditions

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