Skip to content

Thyroid hormone replacement

Levothyroxine: uses, side effects & precautions

Also known as Synthroid, Euthyrox, Eltroxin, Levoxyl, L-thyroxine, T4.

Esta información es solo orientativa de carácter general y no constituye un consejo médico. Consulta siempre a un profesional sanitario cualificado para cualquier asunto médico personal. En caso de emergencia, llama al número de emergencias de tu zona.

What it is used for

  • Underactive thyroid (hypothyroidism)
  • Thyroid hormone replacement after thyroid surgery or radioactive iodine
  • Certain types of goitre and thyroid cancer follow-up (when prescribed)

How it works

It is a synthetic version of thyroxine, the hormone your thyroid gland normally makes. It replaces missing thyroid hormone so your body's metabolism works normally.

How it is taken

Usually taken as a once-daily tablet, and also available as a liquid or capsule. It is generally taken on an empty stomach with water, often before food. Take it exactly as your doctor or pharmacist directs, at the same time each day, and do not change the brand or dose without advice, as regular blood tests guide adjustments.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Usually none when the dose is correct
  • Symptoms of too much hormone if the dose is too high, such as palpitations, tremor, sweating, or weight loss
  • Symptoms of too little if the dose is too low, such as tiredness, weight gain, or feeling cold

Serious effects — get help

  • Chest pain
  • Fast or irregular heartbeat
  • Severe shortness of breath
  • Signs of a serious allergic reaction

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Calcium and iron supplements (separate by several hours)
  • Some indigestion remedies and antacids
  • Some medicines for osteoporosis, cholesterol, and seizures
  • Certain diabetes medicines may need dose review
  • Soya, coffee, and high-fibre foods taken too close to the dose can reduce absorption

Who should take care

  • Tell your clinician if you have heart disease, as doses are usually started low and increased slowly
  • Dose needs often change during pregnancy, so tell your clinician promptly if you are or might be pregnant
  • Take it consistently in relation to food and other medicines
  • Do not stop suddenly without advice

Frequently asked questions

Do I take this for life?
For most people with an underactive thyroid it is a lifelong treatment, with the dose adjusted over time based on blood tests.
Why must I take it on an empty stomach?
Food and some supplements reduce how much is absorbed, so taking it consistently away from food keeps levels steady.
What if I miss a dose?
Take it when you remember unless it is almost time for the next dose. Do not double up. Ask your pharmacist if unsure.
Can I switch brands?
It is best to stay on the same brand or formulation where possible, as small differences can affect your levels. Discuss any change with your clinician.
Is Levothyroxine safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

Related conditions

Related medicines

See a doctor online now