What it is used for
- Prevention of malaria for travellers
- Treatment of uncomplicated malaria caused by P. falciparum
How it works
Atovaquone and proguanil act on different steps of the malaria parasite's energy production and DNA building, and together they block the parasite from surviving and multiplying.
How it is taken
Taken as oral tablets, including a smaller paediatric tablet for children, usually with food or a milky drink to aid absorption. For prevention it is started shortly before travel and continued for a period after leaving the area; for treatment it is a short daily course. Take it exactly as your doctor or pharmacist directs.
No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.
Common side effects
- Headache
- Nausea or vomiting
- Abdominal pain
- Diarrhea
- Mouth ulcers
- Dizziness
- Vivid dreams
Serious effects — get help
- Signs of a severe allergic reaction such as facial swelling or breathing difficulty — seek emergency care
- Severe or persistent vomiting that prevents keeping the medicine down — contact your clinician
- Severe skin reaction — seek emergency care
- Yellowing of the skin or eyes or signs of liver problems — seek urgent care
If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.
Interactions to watch
- Rifampicin and rifabutin (can reduce effectiveness)
- Tetracycline antibiotics
- Metoclopramide
- Some HIV medicines
- Warfarin and other blood thinners (monitoring may be needed)
Who should take care
- Tell your clinician about severe kidney problems, as it may not be suitable
- Discuss liver problems
- Take with food and consider a repeat dose plan if vomiting occurs — ask your clinician
- Inform your clinician if pregnant or breastfeeding
- Mention all other medicines you take