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Nonsteroidal anti-inflammatory drug (NSAID)

Naproxen: uses, side effects & precautions

Also known as Aleve, Naprosyn, Anaprox, Naprogesic.

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What it is used for

  • Pain and inflammation from arthritis and other joint conditions
  • Muscle and back pain, sprains and strains
  • Period pain
  • Pain from gout attacks
  • Headache and dental pain

How it works

Naproxen blocks the COX enzymes that produce prostaglandins, reducing pain, inflammation and fever. It is longer-acting than some other NSAIDs, so doses are needed less often.

How it is taken

Available as standard and gastro-resistant tablets, and oral suspension. Take it exactly as your doctor, pharmacist or the label directs, usually with or after food to protect the stomach. Swallow gastro-resistant tablets whole.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Indigestion, heartburn or stomach discomfort
  • Nausea
  • Headache or dizziness
  • Drowsiness

Serious effects — get help

  • Stomach or gut bleeding or ulcers (black stools, vomiting blood, severe abdominal pain)
  • Heart attack or stroke warning signs (chest pain, breathlessness, one-sided weakness)
  • Serious allergic reaction or asthma flare (swelling, wheezing, difficulty breathing)
  • Signs of kidney problems (reduced urination, swelling)
  • Severe skin reactions

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Other NSAIDs and aspirin
  • Blood thinners and other antiplatelet drugs
  • Some blood pressure medicines and diuretics
  • Corticosteroids and SSRIs (bleeding risk)
  • Lithium and methotrexate
  • Alcohol

Who should take care

  • Avoided in late pregnancy; use earlier in pregnancy or while breastfeeding only on clinician advice
  • Tell your doctor about ulcers, heart disease, high blood pressure, asthma, or kidney or liver problems
  • Use the lowest effective amount for the shortest time
  • Older adults are more prone to side effects
  • Seek urgent care for chest pain, stroke symptoms or gut bleeding

Frequently asked questions

How is naproxen different from ibuprofen?
Both are NSAIDs, but naproxen lasts longer so it is taken less often. Choice depends on your condition, other medicines and risk factors — ask your pharmacist or doctor.
Is naproxen good for period pain?
NSAIDs like naproxen are commonly used for period pain because they reduce the prostaglandins involved. Follow the label and check with a pharmacist if you have stomach or other risk factors.
Can I take naproxen long term for arthritis?
Long-term use is sometimes prescribed but needs medical supervision to monitor stomach, heart and kidney risks, often with stomach protection. Do not self-manage long-term use.
Does naproxen thin the blood?
It can reduce platelet stickiness and increase bleeding risk, especially with blood thinners. Tell your clinician about all medicines you take.
Is Naproxen safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

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