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Topical retinoid

Adapalene: uses, side effects & precautions

Also known as Differin, Epiduo (with benzoyl peroxide).

Diese Informationen dienen ausschließlich der allgemeinen Orientierung und stellen keine medizinische Beratung dar. Konsultieren Sie bei persönlichen gesundheitlichen Anliegen stets eine qualifizierte medizinische Fachkraft. Wählen Sie im Notfall Ihre örtliche Notrufnummer.

What it is used for

  • Mild to moderate acne
  • Blackheads and whiteheads
  • Clogged pores and inflamed spots

How it works

Adapalene is a vitamin-A-related medicine that helps skin cells turn over normally, unblocking pores and calming the inflammation behind acne.

How it is taken

Comes as a gel or cream, sometimes combined with benzoyl peroxide. Apply a thin layer to clean, dry, affected skin exactly as the label or your clinician directs, usually in the evening. Skin may take several weeks to improve and can get worse before it gets better; use a moisturizer and sun protection.

No doses here on purpose. The right strength and schedule depend on you — only a doctor or pharmacist should set them. Always follow your prescription and the label.

Common side effects

  • Dryness, peeling and flaking
  • Redness, burning or stinging, especially early on
  • Increased skin sensitivity to sunlight

Serious effects — get help

  • Severe irritation, blistering, crusting or swelling
  • Signs of an allergic reaction such as facial swelling, hives or difficulty breathing

If a reaction is severe — for example trouble breathing, swelling of the face or throat, or collapse — go to the nearest emergency room now or call your local emergency number. Do not wait for an online consultation.

Interactions to watch

  • Other drying, exfoliating or strong acid products used at the same time can increase irritation
  • Wax-based hair removal on treated skin may cause damage

Who should take care

  • Use sun protection, as skin becomes more sun-sensitive
  • Tell your clinician if you are pregnant, planning pregnancy or breastfeeding before use
  • Apply a thin layer only; more does not work faster and increases irritation
  • Avoid the eyes, lips, nostrils and broken skin

Frequently asked questions

Why did my acne get worse at first?
An initial flare or 'purge' can happen in the early weeks as skin adjusts. It usually settles; if it is severe, ask your clinician.
Can I use it while pregnant?
Tell your clinician before use if you are pregnant or planning pregnancy, as retinoid products generally need professional guidance in this situation.
Do I need sunscreen with it?
Yes. Adapalene makes skin more sensitive to sunlight, so daily sun protection on treated areas is important.
How long until it works?
It often takes several weeks of consistent nightly use. If there is no benefit after the period on the label, seek advice.
Is Adapalene safe to take?
For most people it is safe when taken exactly as a doctor or pharmacist advises and as printed on the label. Tell your clinician about your other medicines and health conditions, and seek urgent care for any serious reaction.

Related conditions

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